杨瑜涛
一、个人简介
杨瑜涛, 女，博士，副研究员，硕士生导师，2014年毕业于山西大学化学化工学院，同年引进到河北大学化学与环境科学学院工作，主要从事于小分子荧光探针的构建及其生物成像应用研究。迄今为止，以第一作者或通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Anal. Chem., Chem. Eng. J., Biosens. Bioelectron., Chinese chem. Lett.等知名学术期刊发表SCI收录论文30余篇；主持多项科研项目，其中包括国家自然科学基金面上/青年项目、河北省自然科学基金面上/青年项目。
联系方式 E-mail: yutaoyang2016@163.com
二、研究方向
荧光探针的构建及其生物应用研究
三、代表性论文
1. Yutao Yang, Tingting Zhou, Ming Jin, Keyan Zhou, Dandan Liu, Xue Li, Fangjun Huo, Wei Li, Caixia Yin*, A thiol-chromene “click” reaction triggered self-immolative for NIR visualization of thiol flux in physiology and pathology of living cells and mice, J. Am. Chem. Soc., 2020, 142: 1614-1620.
2. Yutao Yang,# Ming Ma, Lei Shen, Jusung An,# Eunji Kim, Hongmei Liu,* Ming Jin, Shuxiang Wang, Jinchao Zhang, Jong Seung Kim,* and Caixia Yin*, A Fluorescent Probe for Investigating the Role of Biothiols in Signaling Pathways Associated with Cerebral Ischemia-Reperfusion Injury, Angew. Chem. Int. Ed., 2023, e202310408.
3. Lei Shen, Ming Ma, Keyan Zhou, Ming Jin, Shuxiang Wang, Hongmei Liu *, Yutao Yang*, Cysteine triggered cascade reaction forming coumarin: Visualization of cysteine fluctuation in alcoholic liver disease by a NIR fluorescent probe, Spectrochim. Acta A, 2025, 324, 124974.
4. Lei Shen, Hongmei Liu, Ming Jin, Jinchao Zhang, Caixia Yin, * Shuxiang Wang, * Yutao Yang*，“Three-in-one”strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone，Chinese Chem. Lett., 2024, 35, 109572.
5. Yutao Yang, Keyan Zhou, Ming Ma, Hongmei Liu, Ming Jin, Caixia Yin*, Shuxiang Wang,* Jinchao Zhang*, Thiol “click” chromene mediated cascade reaction forming coumarin for in-situ imaging of thiol flux in drug-induced liver injury, Chem. Eng. J., 2023, 452, 139020.
6. Yutao Yang, Yan Zhang, Ming Ma, Hongmei Liu, Kun Ge, Chunfang Zhang, Ming Jin, andan Liu, Shuxiang Wang*, Caixia Yin*, Jinchao Zhang*, Synergistic modulation by halogens and pyridine crossing the blood-brain barrier for in situ visualization of thiol flux in the epileptic brain, Anal. Chem., 2022, 94: 14443-14452.
7. Keyan Zhou, Yutao Yang*, Tingting Zhou, Ming Jin, Caixia Yin*, Design strategy of multifunctional and high efficient hydrogen sulfide NIR fluorescent probe and its application in vivo, Dyes Pigments, 2021, 185: 108901.
8. Tingting Zhou, Yutao Yang*, Keyan Zhou, Ming Jin, Mengnan Han, Wei Li*, Caixia Yin*, Efficiently mitochondrial targeting fluorescent imaging of H2S invivo based on a conjugate-lengthened cyanine NIR fluorescent probe, Sens. Actuators B Chem., 2019, 301: 127116.
9. Tingting Zhou, Yutao Yang,* Keyan Zhou, Wenzhi Xu, Wei Li*, An “off-on” fluorescent probe for biothiols and its application in Bioimaging, Chin. J. Org. Chem., 2019, 39 (12), 3498-3504.
10. Yutao Yang, Bozan Bai, Ming Jin, Zhidong Xu, Jinchao Zhang, Wei Li, Wenzhi Xu*, Xiang Wang and Caixia Yin**, Fluorescent imaging of Au3+ in living cells with two new high selective Au3+ probes. Biosens. Bioelectron., 2016, 86: 939-943.
四、科研项目
1. 国家自然科学基金面上项目（22177025），2022-2025，主持；
2. 国家自然科学基金青年项目（21807021）， 2019 -2021，主持；
3. 河北省自然科学基金面上项目（B2020201074），2020-2022，主持；
4. 河北省自然科学基金青年项目（B2017201093），2017-2019，主持；
5. 河北省高等学校科学技术研究青年基金项目（QN2016112），2016-2018，主持；
6. 中国博士后科学基金第59 批面上项目（2016M591402），2016-2017，主持；
7. 河北省博士后科研项目择优资助项目（B2015005001），2015-2017主持；
8. 河北大学多学科交叉研究项目（DXK202113），2022-2024，主持；
9. 教育部重点实验室主任基金（MCMDZR-2024003），2024-2026，主持。
