严景丽

一、个人简介

严景丽, 中国科学院化学研究所(2010-2013)，北京大学博士后(2013-2015)。现为副教授，硕士研究生导师。迄今为止，发表SCI收录论文14篇；获授权中国发明专利2项，先后主持了国家自然科学基金、河北省自然科学基金、博士后面上基金、公安部开放课题，共计4项课题。

联系方式：E-mail: yanjinglichem@hbu.edu.cn

yanjinglichem@163.com

二、主讲课程及研究方向

1.主讲课程：仪器分析、分析化学、基础化学分析实验、基础仪器分析实验

2.研究方向：生化分析:DNA甲基化及RNA甲基化的分析研究，

光谱分析：单原子材料的合成，化学发光。

三、代表性论文

1. Jiahui Zhao, Jingli Yan,* Jing Li, Guoyu Shi, Ming Su, Chenghui Liu,* and Guifang Jia*, Selective Ligase-Based Sample Processing-Free Discrimination and Detection of Site-Specific DNA 5‑Hydroxymethylcytosine, Analytical Chemistry, 2024, 96, 13285−13290.

2. Lin Sun, Jingli Yan*, Yilin Liu, Ruipeng Wang, Yongqiang Cheng*, Chemical oxidation-free site-specific 5-hydroxymethylcytosine assay, Sensors & Actuators: B. Chemical 353 (2022) 131161.

3. Wenyue Zhang, Wenhui Hao, Xuetao Liu, Xiru Sun, Jingli Yan* and Yucong Wang*, Visual detection of miRNAs using enzyme-free amplification reactions and ratiometric fluorescent probes. Talanta, 2020, 219, 121332.

4. Zhenhao Zhang, Jingli Yan* and Zhengping Li*. Peroxotungstate oxidation- mediated two-phase amplification system (POM-TPAS) for bisulfite-free quantification of locus-specific 5-hydroxymethylcytosine. Chemical Communications, 2020, 56, 3111-3114.

5. Zhenhao Zhang, Xiao Shan, Pengbo Zhang, Weiliang Liu, Jingli Yan* and Zhengping Li*. Highly sensitive quantification of site-specific 5-hydroxymethylcytosine at single-base resolution by HpaII-mediated ligation PCR. Organic & Biomolecular Chemistry, 2019,17, 9849-9853.

6. Weiliang Liu, Jingli Yan*, Zhenhao Zhang, Hongru Pian, Chenghui Liu and Zhengping Li*. Identification of a selective DNA ligase for accurate recognition and ultrasensitive quantification of N6-methyladenosine in RNA at one-nucleotide resolution. Chemical Science, 2018, 9, 3354-3359.

7. Hui Wen, Hui Wang, Honghong Wang, Jingli Yan*, Hui Tian and Zhengping Li*. Ultrasensitive detection of site-specific DNA methylation by loop-mediated isothermal amplification. Analytical Methods, 2016, 8, 5372-5377.

8. Yue Huang^†, Jingli Yan^†, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, and Cai-Guang Yang*, Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5, Nucleic Acids Research, 2015, 43, 373–384.

四、主持或参与的项目

1.主持河北省面上项目：恒温的可视的5-羟甲基胞嘧啶分析方法的建立及应用。

2.主持国家青年基金：mRNA中N6-甲基腺苷的系统分析及其生物功能研究。

五、获奖

新型生物标志物microRNA的高灵敏度、高选择性的分析,2017年河北省自然科学奖二等奖（第五名）。