李娟娟
一、个人简介
李娟娟，南开大学博士（2019-2022），南开大学博士后(2022-2023），于2023年11月入职河北大学化学与材料科学学院。现为河北大学校聘副教授，硕士研究生导师。主要从事糖基修饰超分子功能材料的研究。迄今为止，在Nat. Commun., ACS Nano, J. Control. Release, 等知名学术期刊上共发表SCI论文30余篇。其中，第一作者/通讯论文十余篇。主持河北大学高层次人才科研启动项目1项，国家自然科学基金（青年）项目1项，河北省教育厅青年拔尖人才项目1项，河北省自然科学基金青年科学基金项目（B类）1项。任《Glycoscience & Therapy》杂志青年编委。
联系方式：E-mail: juanjuanli0313@163.com
二、研究方向
1. 糖基修饰超分子功能材料的设计合成
2. 药物递送
三、代表性研究成果：
11. Jiansen Lu#, Juan-Juan Li#, Hao Pan#, Hongliang Liang, Tian Han, Weiye hang, Meng Fan, Song Zhang, Dong-Sheng Guo, Ke-Rang Wang, Wen Hou*, Zhongyang Shen*. A hepatocyte targeted and hypoxia responsive host-guest drug delivery system for the treatment of liver ischemia reperfusion injury. Chem. Eng. J., 2026, 389, 173314.
10. Jing Liu#, Fangqian Yin#, Yanbin Ren, Mengqiong Ming, Houhuan Xie, Xin Cai, Juan-Juan Li*, Dong-Sheng Guo*, Ke-Rang Wang*. Enhanced antitumor efficacy and reduced myelosuppression by a supramolecular complex composed of azocalix[4]arene and sunitinib. J. Med. Chem., 2025, 68, 24456-24468.
9. Jing Liu#, Juan-Juan Li#, Hai-Qing Li, Meiqi Yang, Kai Zhang, Fangqian Yin,Yanbin Ren, Mengqiong Ming, Dong-Sheng Guo* and Ke-Rang Wang*, Acid-tolerant and hypoxia-responsive drug delivery system based on sulphobetaine-modified azocalix[4]arene for treating ulcerative colitis, Nano Today, 2025, 64, 102801.
8. Xihan Xu#, Juan-Juan Li#, Jiamin Li#, Hui-Yan Zhang, Yilin Qi, Bing-Sen Shi, Tianqi Li, Shan-Shan Su, Weitao Zhao, Chang Che, Zhongying Gong, Huiyu Liu *, Ke-Rang Wang*, Dong-Sheng Guo*, Xue Xue*, Enhanced Subacute Ischemic Stroke Treatment via Multistage Drug Delivery System Design for Combination Therapy, Sci. China Chem., 2025, 68, 3162-3174.
7. Meng-Meng Chen#, Xingchen Tang#, Juan-Juan Li#, Fang-Yuan Chen, Ze-Tao Jiang, Rong Fu, Hua-Bin Li, Xin-Yue Hu, Wen-Chao Geng*, Dong-Sheng Guo*, Active targeting tumor therapy using host-guest drug delivery system based on biotin functionalized azocalix[4]arene, J. Control. Release, 2024, 368, 691-702.
6. Shihui Li#, Juan-Juan Li#, Ying-Ying Zhao, Meng-Meng Chen, Shan-Shan Su, Shun-Yu Yao, Ze-Han Wang, Xin-Yue Hu, Wen-Chao Geng, Wei Wang*, Ke-Rang Wang* and Dong-Sheng Guo*. Supramolecular integration of multifunctional nanomaterial by mannose-decorated azocalixarene with Ginsenoside Rb1 for synergistic therapy of rheumatoid arthritis. ACS Nano, 2023, 17, 25468-25482.
5. Jianshuang Guo#, Juan-Juan Li#, Ze-Han Wang, Yang Liu, Yu-Xin Yue, Hua-Bin Li, Xiu-He Zhao, Yuan-Jun Sun, Ya-Hui Ding, Dong-Sheng Guo*, Liang Wang*, Yue Chen. Dual hypoxia-responsive supramolecular complex for cancer target therapy. Nat. Commun., 2023, 14, 5634.
4. Juan-Juan Li#, Rui-Xue Rong#, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu*, Ke-Rang Wang*, Dong-Sheng Guo*. Triple targeting host-guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation. Mater. Horiz., 2023, 10, 1689-1696.
3. Juan-Juan Li#, Yuqing Hu#, Bing Hu, Wenbo Wang, Haiqi Xu, Xin-Yue Hu, Fei Ding, Hua-Bin Li, Ke-Rang Wang*, Xinge Zhang*, Dong-Sheng Guo*. Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer. Nat. Commun., 2022, 13, 6279.
2. Tian-Xing Zhang#, Juan-Juan Li#, Hua-Bin Li and Dong-Sheng Guo*. Deep cavitand calixarene–solubilized fullerene as a potential photodynamic agent. Front. Chem., 2021, 9, 710808.
1. Juan-Juan Li, Ke-Rang Wang*, Ren-Feng Li, Jian-Xing Yang, Min Li, Hong-Xin Zhang, Zhi-Ran Cao and Xiao-Liu Li*. Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative. J. Mater. Chem. B, 2019, 7, 1270.
四、科研项目
4. 河北省自然科学基金青年科学基金项目（B类，原优青），乏氧激活糖基修饰抗生素前药的合成及抗菌活性研究，B2025201015 （2025.01-2027.12，主持人）
3.河北省教育厅青年拔尖人才项目，乏氧激活深穴杯芳烃-簇糖类前药的合成及抗菌研究，BJ2025040（2025.01-2027.12，主持人）
2. 国家自然科学基金项目，乏氧激活深穴杯芳烃-簇糖类衍生物的合成及超分子复合前药抗菌活性研究，22401071（2025.01-2027.12，主持人）
1. 河北大学高层次人才科研启动项目（2023.12-2027.12，主持人）
