霍树营
1. 霍树营，博士，教授。课题组主要在多肽化学和反应动力学两方面进行研究。在多肽化学研究方向，为了解决多对二硫键选择性合成问题，课题组发展了有机硒化合物和四价铂配合物两类高效合成试剂，用于多肽多对二硫键的选择性合成。发展、建立了SeODR 和BA-ODr法精准、高效、选择性合成多对二硫键、硫醚桥联的多环肽的方法。同时，发展、建立了四价铂配合物选择性脱除多肽巯基保护基反应用于环肽、蛋白质的高效合成，建立了精准的合成策略。在反应动力学研究方向，建立了四价铂配合物与含巯基、硫醚、硒醚化合物的反应动力学和反应机理的研究方法，为四价铂配合物在多肽化学和蛋白质化学中的应用奠定了坚实的理论基础。课题组主持、完成国家基金、河北省自然科学基金等10余项，相关研究成果发表学术论文30余篇，申请、授权专利5项。
2. 主讲课程：
物理化学，物理化学基础实验
3. 代表性学术论文：
(1). Yueyue Xing, Tianyu Bo, Nan Zhang, Meiqi Wu, Jiawei Wang, Shigang Shen*, Yafang Wang, Changying Song, Tiesheng Shi*, Shuying Huo*. Benzeneseleninic acid used as an oxidizing and deprotecting reagent for the synthesis of multi-cyclic peptides constrained by multiple disulfide bonds and thioether bridges. Org. Chem. Front., 2024, 11, 4423-4435.
(2). Yafang Wang, Changying Song, Yueyue Xing, Shigang Shen,* Tianyu Bo, Nan Zhang, Jixu Wang, Tiesheng Shi,* and Shuying Huo*. L-Methionine Selenoxide as an Oxidizing and Deprotection Reagent for Synthesis of Multiple Disulfide Bonds in Peptides. J. Org. Chem., 2023, 88, 8123-8132.
(3).Dongying Ma, Jingjing Sun, Shigang Shen,* Hua Chen, Wenzhi Xu, Yafang Wang, Changying Song, Tiesheng Shi,* and Shuying Huo*. Deprotection of S‐Acetamidomethyl and 1,3-Thiazolidine-4-Carbonyl Protecting Groups from Cysteine Side Chains in Peptides by trans-[PtX2(CN)4]2−: One-Pot Regioselective Synthesis of Disulfide Bonds. J. Org. Chem., 2022, 87, 1470−1476.
(4). Jingjing Sun, Changying Song, Dongying Ma, Shigang Shen*, Shuying Huo*. Expanding the toolbox for peptide disulfide bonds formation via L-methionine selenoxide oxidation. J. Org. Chem., 2021, 86, 4035-4044.
(5). Changying Song, Jingjing Sun, Xiaowei Zhao, ShuyingHuo* and Shigang Shen*. A study to develop platinum(IV) complex chemistry for peptide disulfide bonds formation. Dalton Trans., 2020, 49, 1736-1741.
(6). Changying Song, Dongying Ma, Yafang Wang, Shigang Shen, and Shuying Huo*. Thiuram Disulfides for the Fast and Efficient Synthesis of Peptide Disulfide Bonds Under Aqueous Conditions. Eur. J. Org. Chem., 2023, 26, e202301024.
